Curcumin 95

What You Must Know About Curcumin 95

Curcumin Benefits

The world has all its eyes in studying Curcumin, a chemical of the polyphenol family derived from the rhizome Curcuma longa L. The ground product of this root is the common spice known as turmeric. There has been so much interest in the potential health benefits of curcurim and as you may know, there are thousands of research papers written to find more potential.

The purpose of this review is to provide a brief summary of the current knowledge of the effects of curcumin, including curcumin benefits,  as reported in basic science publications, clinical trials, and previous reviews.

Inhibition and Prevention of Cancer    
Colon cancer and polyps
Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis.Clin Gastroenterol Hepatol. 2006.
“Familialadenomatous polyposis is an autosomal-dominant disorder characterized by the development of hundreds of colorectal adenomas and eventual colorectal cancer. Regression of adenomas in this syndrome occurs with the administration of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors, but these compounds can have considerable side effects. Five familialadenomatous polyposis patients with prior colectomy (4 with retained rectum and 1 with an ileal anal pouch) received curcumin 480 mg and quercetin 20 mg orally 3 times a day. All 5 patients had a decreased polyp number and size from baseline after a mean of 6 months of treatment with this combination.”
Breast cancer                                                                                                      
Curcumin helped stop the spreading of breast cancer tumor cells to the lungs of mice and Bharat Aggarwal of the Department of Experimental Therapeutics at the University of Texas M.D. Anderson Cancer Center in Houston said that they have already started testing it to people. “Earlier studies suggest that people who eat diets rich in turmeric have lower rates of breast cancer, prostate cancer, lung cancer and colon cancer.”
According to Clin Cancer Res. 2009. Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, M. D. Anderson Cancer Center, Houston, Texas, USA, “Two naturally occurring compounds, curcumin, the active ingredient in the spice turmeric, and the green tea extract epigallocatechin-3-gallate, have marked effects on the apoptotic machinery in chronic lymphocytic leukemia. These results provide a preclinical foundation for future clinical use of these compounds in this disease.”

Melanoma influence                                                                           
Laboratory tests showed that curcumin made melanoma skin cancer cells to more likely self-destruct in a process known as apoptosis.

Prostate cancer                                                                          
Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro.  Nutr Cancer. 2004. Missouri University Center for Phytonutrient and Phytochemical Studies, University of Missouri, Columbia “Prostate cancer is an important public health problem in the United States. Seven phytoestrogens found in common herbal products were screened for estrogen receptor binding and growth inhibition of androgen-insensitive (PC-3) and androgen-sensitive human prostate tumor cells. In a competitive 3H-estradiol ligand binding assay using mouse uterine cytosol, 2.5 M quercetin, baicalein, genistein, epigallocatechin gallate (EGCG), and curcumin displaced > 85% of estradiol binding, whereas apigenin and resveratrol displaced > 40%.

From growth inhibition studies in LNCaP cells, apigenin and curcumin were the most potent inhibitors of cell growth, and EGCG and baicalein were the least potent. In PC-3 cells, curcumin was the most potent inhibitor of cell growth, and EGCG was the least potent. In both cell lines, significant arrest of the cell cycle in S phase was induced by resveratrol and EGCG and in G2M phase by quercetin, baicalein, apigenin, genistein, and curcumin. Induction of apoptosis was induced by all of the 7 compounds in the 2 cell lines. Androgen responsiveness of the cell lines did not correlate with cellular response to the phytoestrogens. In conclusion, these 7 phytoestrogens, through different mechanisms, are effective inhibitors of prostate tumor cell growth.”

Curcumin prevents interleukins from promoting inflammation.
Safety and Absorption                                                                        
According to Pure Prescriptions Natural Health Solutions: It has been estimated that the average daily intake of turmeric in the Indian diet is about 2-2.5g which equates to about 60-100mg of curcumin daily.
•Curcumin at a dose of 1.8g/kg/day was given to rats and 0.9g/kg/day to monkeys with no toxicity or adverse events.

•A phase I clinical trial in humans was carried out to determine associated toxicity with high dose curcumin administration. Subjects were fed 8000mg of curcumin per day and experienced no toxic effects.

•Several clinical studies have used doses of 1000-2000mg/day of pure curcumin with no reports of toxic effects or adverse outcomes in humans.

•Absorption (blood levels) after oral administration was highest 1-2 hours after dosing and decreased to undetectable after 12 hours.
According to Supplement Updates by Jarret Morrow, M.D., you may experience some of these benefits:
•Natural treatment for arthritis, resulting from curcumin’s anti-inflammatory properties;

•Faster healing of wounds and damaged skin;

•Prevention or reduction of amyloyd plaque buildup in the brain, which causes Alzheimer’s disease;

•Reduction of insulin resistance due to antioxidant properties, contributing to the prevention of Type 2 diabetes;

•Increased immune function due to curcumin’s natural antioxidant properties, which attack both bacteria and viruses, as well as fungi;

•More successful weight management due to stimulation of the metabolism.

Aditionally, Alzheimers disease may also be prevented by curcumin. Research studies have shown that Curcumin directly decreases amyloid accumulation. It also helps with arthritis by reducing COX-2 enzyme in the body.

The full benefits of Curcumin are not yet fully understood. But given this current body of evidence, curcumin, may provide us a safe, natural, and effective therapy for many diseases that harass the society.